科研团队
本团队立足河南道地大宗中药材资源，为河南省中药材产业提质增效贡献力量。开展怀山药、怀地黄等中药材道地性的形成机制研究；基于基因组和代谢组技术挖掘道地药材优良种质资源性状调控基因及其活性物质的提取分离、结构鉴定、活性评价和开发利用等研究。团队先后年主持国家自然基金面上项目、NSFC-河南联合基金项目和青年项目、河南省重点研发专项、河南省自然科学基金重点项目、河南省科技研发联合基金、河南省科技攻关项目等国家级、省部级课题30余项（包括国家自然科学基金项目6项）。在Food Hydrocolloids、Food Science and Human Wellness、International Journal of Biological Macromolecules等国内外知名期刊上发表论文100余篇；授权国家发明专利8项；出版专著和教材6部。培养硕士研究生20多人，其中2人获得河南省优秀硕士论文。
研究方向：
1. 怀山药、怀地黄道地性形成机制和品质提升研究
2. 中药活性物质开发利用研究
3. 中药多糖结构与活性研究
4. 中药内生真菌化学与生物学研究
科研人员组成：
带头人：麻兵继
成 员：王丽、刘淼、文春南、高洁、阮元
代表性成果：
1. 怀山药“优型-优质”研究；
2. 怀地黄多糖结构、活性与开发利用研究。
代表性论文（近三年）：
1. Jie Gao, Miao Liu, Shuya Miao, et al. The Dioscorea opposita genome provides insights into anthocyanin biosynthesis in Tiegun yam. Medicinal Plant Biology, 2025, 4, e028.
2. Tian Ruo-Dan, Zhao Ying-Fei, Wang Fei-Fan, et al. New α-pyrones from endophytic Fusarium sp. L46 isolated from Dioscorea opposita. Chemistry & Biodiversity, 2025, 22, e00223.
3. 苗姝雅, 高洁, 马洪旭, 等. 铁棍山药花青素合成酶基因DoANS的克隆及其功能初步验证. 中药材, 2025, 48(9): 2146-2153.
4. Jia Yahui, Zhang Zhiqiang, Zhang Siming, et al. Effects of polysaccharide from hot-compressed steamed Rehmannia glutinosa on the immune system and gut microbiota in an immunosuppressed mice model. International Immunopharmcology, 2024, 142, 113202.
5. Wang Li, Zhang Zhiqiang, Zhao Wanlin, et al. Physicochemical, rheological, antioxidant and immunological properties of four novel non-inulin (poly)saccharides from Asparagus cochinchinensis. International Journal of Biological Macromolecules, 2024, 258, 129034.
6. Tian Ruo-Dan, Sheng Meng-Ke, Zhao Ying-Fei, et al. α-pyrone derivatives from the endophytic Fusarium sp. L33 isolated from Dioscorea opposita, Phytochemistry Letters, 2024, 62, 14-17.
7. Zhao Zuowei, Qian Yanyan, Ruan Yuan, et al. Physicochemical properties and biological activities of polysaccharides from the peel of Dioscorea opposita Thunb. extracted by four different methods. Food Science and Human Wellness, 2023, 12, 130-139.
8. Wang Li，Zhao Zuowei, Zhao Haoqiang, et al. Pectin polysaccharide from Flos Magnoliae (Xin Yi, Magnolia biondii Pamp. flower buds): Hot-compressed water extraction, purification and partial structural characterization. Food Hydrocolloids, 2022, 122, 107061.
9. Qian Yanyan, Wang Li, Zhang Zhiqiang, et al. Physical-chemical properties of heteropolysaccharides from different processed forms of Rehmanniae radix. Process Biochemistry, 2022, 121, 481-492.
10. Li Xinxin, Zhang Zhiqiang, Li Wang, et al. Three-phase extraction of polysaccharide from Stropharia rugosoannulata: Process optimization, structural characterization and bioactivities. Frontiers in Immunology, 2022, e994706.
研究方向：
1. 怀山药、怀地黄道地性形成机制和品质提升研究
2. 中药活性物质开发利用研究
3. 中药多糖结构与活性研究
4. 中药内生真菌化学与生物学研究
科研人员组成：
带头人：麻兵继
成 员：王丽、刘淼、文春南、高洁、阮元
代表性成果：
1. 怀山药“优型-优质”研究；
2. 怀地黄多糖结构、活性与开发利用研究。
代表性论文（近三年）：
1. Jie Gao, Miao Liu, Shuya Miao, et al. The Dioscorea opposita genome provides insights into anthocyanin biosynthesis in Tiegun yam. Medicinal Plant Biology, 2025, 4, e028.
2. Tian Ruo-Dan, Zhao Ying-Fei, Wang Fei-Fan, et al. New α-pyrones from endophytic Fusarium sp. L46 isolated from Dioscorea opposita. Chemistry & Biodiversity, 2025, 22, e00223.
3. 苗姝雅, 高洁, 马洪旭, 等. 铁棍山药花青素合成酶基因DoANS的克隆及其功能初步验证. 中药材, 2025, 48(9): 2146-2153.
4. Jia Yahui, Zhang Zhiqiang, Zhang Siming, et al. Effects of polysaccharide from hot-compressed steamed Rehmannia glutinosa on the immune system and gut microbiota in an immunosuppressed mice model. International Immunopharmcology, 2024, 142, 113202.
5. Wang Li, Zhang Zhiqiang, Zhao Wanlin, et al. Physicochemical, rheological, antioxidant and immunological properties of four novel non-inulin (poly)saccharides from Asparagus cochinchinensis. International Journal of Biological Macromolecules, 2024, 258, 129034.
6. Tian Ruo-Dan, Sheng Meng-Ke, Zhao Ying-Fei, et al. α-pyrone derivatives from the endophytic Fusarium sp. L33 isolated from Dioscorea opposita, Phytochemistry Letters, 2024, 62, 14-17.
7. Zhao Zuowei, Qian Yanyan, Ruan Yuan, et al. Physicochemical properties and biological activities of polysaccharides from the peel of Dioscorea opposita Thunb. extracted by four different methods. Food Science and Human Wellness, 2023, 12, 130-139.
8. Wang Li，Zhao Zuowei, Zhao Haoqiang, et al. Pectin polysaccharide from Flos Magnoliae (Xin Yi, Magnolia biondii Pamp. flower buds): Hot-compressed water extraction, purification and partial structural characterization. Food Hydrocolloids, 2022, 122, 107061.
9. Qian Yanyan, Wang Li, Zhang Zhiqiang, et al. Physical-chemical properties of heteropolysaccharides from different processed forms of Rehmanniae radix. Process Biochemistry, 2022, 121, 481-492.
10. Li Xinxin, Zhang Zhiqiang, Li Wang, et al. Three-phase extraction of polysaccharide from Stropharia rugosoannulata: Process optimization, structural characterization and bioactivities. Frontiers in Immunology, 2022, e994706.